Acid-Base – RetroSynthetiX

Acid-Base Ex I. Why do Acid-Base Reactions Proceed Towards the Formation of Weaker Acids and Weaker Bases? – A Thermodynamic Point of View

Monday, 8th May 2017

Contents I. Introduction II. Several Examples III. Calculating the Values of Keq and ∆G IV. Conclusions I. Introduction In Acid-Base VI, I mentioned that as a rule of thumb, stronger acids and bases react with each other to form weaker acids and bases. I believe that even high school students have unknowingly told about this … More Acid-Base Ex I. Why do Acid-Base Reactions Proceed Towards the Formation of Weaker Acids and Weaker Bases? – A Thermodynamic Point of View

Acid-Base XI. Hard and Soft Acids and Bases (HSAB) Theory in Organic Chemistry

Wednesday, 1st March 2017

Contents I. Introduction II. The HSAB Theory and Hard-Hard Soft-Soft Interaction III. The HSAB Theory in Organic Chemistry IV. Application of HSAB Theory: Conjugate Addition V. Conclusion I. Introduction Until now, we have always been talking about acids, bases, and their conjugate pairs; meaning that we have only been talking about Brønsted-Lowry acid-base. Another well-known … More Acid-Base XI. Hard and Soft Acids and Bases (HSAB) Theory in Organic Chemistry

Acid-Base X. Levelling Effect

Wednesday, 22nd February 2017

Contents I. Introduction II. Levelling Effect in Acids III. Levelling Effect in Bases IV. Levelling Effect Overview V. Example of Levelling Effect VI. Conclusion VII. Try It Yourself! I. Introduction We have seen the relationship between pKa, pKb, and pKsolv in Acid-Base VIII. We have also seen that acids and bases can have different strength … More Acid-Base X. Levelling Effect

Acid-Base IX. Acidity, Basicity, and Solvent – Part 2

Friday, 17th February 2017

Contents I. Introduction II. Acids and Bases Have Different Strength in Different Solvents II.1. Comparison of Acid Strength in Water and Acetic Acid II.2. Comparison of Base Strength in Water and Ammonia II.2.1. Base Strength Using Kb and pKb II.2.2. Base Strength Using KaH and pKaH III. Conclusion I. Introduction Before we see the actual … More Acid-Base IX. Acidity, Basicity, and Solvent – Part 2

Acid-Base VIII. Acidity, Basicity, and Solvent – Part 1

Friday, 10th February 2017

Almost all experiments in the lab needs the aid of a solvent. Just like reactants and products, solvents are also chemicals and they can react with other chemicals. Here we look at how to avoid unwanted side effects caused by the solvent. … More Acid-Base VIII. Acidity, Basicity, and Solvent – Part 1

We can use pKa to predict the course of a reaction. Here we use the deprotonation of acetylene with different bases and predict whether or not the reaction will take place by only using pKa values. … More Acid-Base V. Using pKa to Predict the Course of a Reaction – Part 1

Acid-Base IV. Factors Affecting the Acidity of Organic Compounds

Wednesday, 7th December 2016

We can use pKa to predict the course of a reaction. Here we use the deprotonation of acetylene with different bases and predict whether or not the reaction will take place by only using pKa values. … More Acid-Base IV. Factors Affecting the Acidity of Organic Compounds